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A quick search of ayahuasca tourist and related websites reveals virtually identical statements of this claim: “The use of Ayahuasca has been recorded over 5000 years ago by the natives of Amazon and surrounding areas,” “Ayahuasca has been known to people for over 5000 years,” “This plant medicine has been used for over 5000 years throughout the Amazonian basin,” “Ayahuasca has been used for over 5000 years.” These examples could be multiplied. Just for perspective, the date of 3000 BC would make the origins of the ayahuasca drink as old as the founding of the first Egyptian dynasty, five centuries older than the reign of the Sumerian king Gilgamesh, and almost ten centuries older than the earliest South American devices yet discovered for the ingestion of DMT-containing plants—two pipes found in association with seeds in northwest Argentina, which have been radiocarbon dated to 2130 BC, and which had residues that tested positive for DMT (Torres, 1995, p. And while it is true that the parenteral ingestion of DMT-containing plants is of considerable antiquity in South America, there is no corresponding archeological or documentary evidence prior to the eighteenth century for the combination of a DMT-containing plant with the ayahuasca vine for oral ingestion.
Combining the ingredients of the ayahuasca drink allows the DMT to produce its hallucinogenic effect when ingested orally—a unique solution that apparently developed only in the Upper Amazon.
The gastrointestinal effects of the beta-carboline MAO inhibitors additionally make the ayahuasca drink a powerful emetic and purgative. Writers on ayahuasca have often proposed that the use of the drink is very ancient; the date of about 5000 years BP recurs frequently.